Here are the Disruption of branched-chain amino acid homeostasis promotes the progression of DKD via enhancing inflammation and fibrosis-associated epithelial-mesenchymal transition journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.
Disruption of branched chain amino acid homeostasis promotes meaning, disruption of branched chain amino acid homeostasis promotes synonym, syndesmotic disruption of right ankle, disruption of branched chain amino acid, disruption of branched chain amino acid homeostasis promotes definition, disruption of family by separation or divorce, disruption of branched chain amino acids supplements.
Disruption of branched-chain amino acid homeostasis promotes the progression of DKD via enhancing inflammation and fibrosis-associated epithelial-mesenchymal transition
Background and aims: The disrupted homeostasis of branched-chain amino acids (BCAAs, including leucine, isoleucine, and valine) has been strongly correlated with diabetes with a potential causal role. However, the relationship between BCAAs and diabetic kidney disease (DKD) remains to be established. Here, we show that the elevated BCAAs from BCAAs homeostatic disruption promote DKD progression unexpectedly as an independent risk factor. Methods and
results: Similar to other tissues, the suppressed BCAAs catabolic gene expression and elevated BCAAs abundance were detected in the kidneys of type 2 diabetic mice and individuals with DKD. Genetic and nutritional studies demonstrated that the elevated BCAAs from systemic disruption of BCAAs homeostasis promoted the progression of DKD. Of note, the elevated BCAAs promoted DKD progression without exacerbating diabetes in the animal models of type 2 DKD. Mechanistic studies demonstrated that the elevated BCAA s promoted fibrosis-associated epithelial-mesenchymal transition (EMT) by enhancing the activation of proinflammatory macrophages through mTOR signaling. Furthermore, pharmacological enhancement of systemic BCAAs catabolism using small molecule inhibitor attenuated type 2 DKD. Finally, the elevated BCAAs also promoted DKD progression in type 1 diabetic mice without exacerbating diabetes.
Conclusion: BCAA homeostatic disruption serves as an independent risk factor for DKD and restoring BCAA homeostasis pharmacologically or dietarily represents a promising therapeutic strategy to ameliorate the progression of DKD. © 2024 Elsevier Inc.
Authors : Deng X.; Tang C.; Fang T.; Li T.; Li X.; Liu Y.; Zhang X.; Sun B.; Sun H.; Chen L.
Source : W.B. Saunders
Article Information
| Year | 2025 |
| Type | Article |
| DOI | 10.1016/j.metabol.2024.156037 |
| ISSN | 00260495 |
| Volume | 162 |
You can download the article here
If You have any problem, contact us here