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Monocyte to high-density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney disease
Background: Monocyte to high-density lipoprotein cholesterol ratio (MHR) is considered a novel marker of inflammation. However, whether MHR can predict the risk of diabetic kidney disease (DKD) remains uncertain. Our research aimed to investigate the relationship between MHR and DKD.
Methods: This was a cross-sectional retrospective study of 159 participants with type 2 diabetes mellitus. MHR, urinary albumin-to-creatinine ratio (UACR) and other indexes were measured. According to UACR, participants were divided into normal group (UACR < 30 mg/g), moderately increased group (UACR 30-300 mg/g) and severely increased group (UACR > 300 mg/g). The association between MHR and DKD was analyzed.
Results: MHR was significantly elevated in severely increased albuminuria group (p = 0.029). The prevalence of DKD increased in parallel with the elevation in MHR (p = 0.009). MHR was positively related with DKD in univa riate logistic regression analysis (ORs = 11.27, 95%CI 1.26-101.24, p = 0.031). Multivariable logistic regression analysis showed MHR significantly correlated with DKD (ORs = 6.20, 95%CI 1.49-25.84, p = 0.012). Each quartile elevation in MHR was associated with an increased risk of DKD (ORs = 1.90, 95%CI 1.19-3.01, p = 0.007). In subgroup analyses MHR was a risk factor for DKD, particularly in patients with HbA1c <8.0%. Conclusions: Our findings suggest that MHR can be used as a marker for the presence and progression of DKD. © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Authors : Yang W.; Zhong Y.; Zhou P.; Lu D.
Source : Taylor and Francis Ltd.
Article Information
| Year | 2025 |
| Type | Article |
| DOI | 10.1080/0886022X.2024.2438846 |
| ISSN | 0886022X |
| Volume | 47 |
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