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Chemerin, TNF − α and the degree of albuminuria in patients with diabetic kidney disease
Background: Chronic inflammation has been increasingly recognized as an essential pathogenic mechanism for the development and progression of diabetic kidney disease (DKD). Chemerin is an adipokine which has been suggested to be related to inflammation and has been correlated with the development of diabetic complications. We aimed to explore the potential links between chemerin, TNF – α, as a marker of systemic inflammation, and the level of albuminuria in patients with type 2 diabetes mellitus (T2DM). Method: The study included 84 patients with T2DM and 10 normoalbuminuric non-diabetic controls. Demographic, clinical and laboratory data including chemerin and TNF-α levels were collected.
Results: A total of 84 diabetic patients were enrolled, 32 males (38.1 %), with mean age 57.9 ± 10.7 years. They were divided into 3 groups: A1: 14 with normalbuminuria, A2: 27 with microalbuminuria, and A3: 43 with macroalbuminuria (uACR < 30, 30–300 and > 300 mg/gm respectively). Chemerin and TNF-α levels increased with the progress of albuminuria (control: 21.3 (14.7 –77), A1: 794 (683–925), A2: 1150 (962.9 – 1221.5) and A3: 1466 (1197.5 – 2002.5) ng/ml; p < 0.001) and (control: 77.9 (59 – 96.8), A1: 85.2 (71–116.3), A2: 87.3 (81 – 97.5) and A3: 99 (85.1 – 142.5) pg/ml; p = 0.009) respectively. Among the diabetics, a significant association was evident between serum chemerin and serum TNF-α (r = 0.53; p < 0.001). On linear stepwise regression analysis, chemerin was significantly associated with TNF-α and HbA1c (unstandardized β 10.881 and 272.68 respectively, p < 0.001); and TNF-α was significantly correlated with chemerin, uACR (unstandardized β 0.059 and 0.004 respectively, p < 0.001) and HbA1c (unstandardized β −13.699, p = 0.014).
Conclusion: Our findings suggest a potential role of chemerin and TNF-α in the development and progression of DKD, and thus suppo rt the role of the inflammatory pathway. Larger follow up studies are warranted to further explore the potential links between chemerin, inflammation and DKD. © 2024 Elsevier Ltd
Authors : El-Tahir F.; Esh A.; Ghorab A.; Shendi A.M.
Source : Academic Press
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.1016/j.cyto.2024.156772 |
| ISSN | 10434666 |
| Volume | 184 |
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