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Efficiency of Vascular Endothelial Growth Factor-2549 Insertion/Deletion variation and VEGF level to Predict Retinopathy in Diabetes Mellitus Type 2 Cases
The current work was suggested to study Vascular Endothelial Growth Factor (VEGF) level and VEGF - 2549 Insertion/Deletion (I/D) to Predict Retinopathy in Diabetes Mellitus Type 2 cases, three groups were used to implement the study aim, Diabetes Mellitus Type 2 (DM) with and without retinopathy, and healthy individuals. Glycemic parameters,VEGF level and VEGF -2549 (I/D) were involved in the present study, the findingsdemonstrated that there were significant differences between DM cases and control in all glycemic biomarkers and the VEGF level (p<0.001), in DM with retinopathy significant elevation was showed in VEGF level (p=0.047) and non-sig changes were observed in other parameters. slightly changes in correlation of VEGF with other parameters in case and control group. The VEGF -2549 (I/D) showed non-significant association (p=0.245) of allele (I, D) in study groups while significant association (p=4.44e-04) was observed in DM with and without retinopathy. The Genotypes of VEGF -2549 (I/D) showed low frequent of heterozygote (I/D) in case-control groups and slightly changes in (D/D) and (I/I) (P=0.603). significant association of (I/I) with DM with retinopathy, while (D/D) was associated with DM without retinopathy group (P= 0.034). The effect of VEGF -2549 (I/D) in study biomarkers showed non-sig changes in case and control groups in all parameters (beta =-1.421, p= 0.999), while in DM with and without retinopathy biomarkers showed non-sig differences association by regression test (beta =0.865, p=0.999).
conclusion: from the present results, it can be proposed that VEGF level was elevated in DM with retinopathy, VEGF -2549 (I/D) was significant associated with DM with retinopathy and may be used to predict retinopathy in DM. © 2024 World Researchers Associations. All rights reserved.
Authors : Methaq A.-J.J.; Raad H.N.
Source : World Researchers Associations
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.25303/1911rjbt2570263 |
| ISSN | 22784535 |
| Volume | 19 |
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