Here are the Influence of Dapagliflozin Dosing on Low-Density Lipoprotein Cholesterol in Type 2 Diabetes Mellitus: A Systematic Literature Review and Meta-Analysis journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.
Influence of dapagliflozin dosing definition, influence of dapagliflozin dosing on low density lipoprotein, influence of dapagliflozin 10, influence of dapagliflozin dosing on call, influence of dapagliflozin dosing system, influence of dapagliflozin dosing on low density lipoprotein definition.
Influence of Dapagliflozin Dosing on Low-Density Lipoprotein Cholesterol in Type 2 Diabetes Mellitus: A Systematic Literature Review and Meta-Analysis
A systematic literature review and meta-analysis was performed to evaluate the effects of dapagliflozin on low-density lipoprotein (LDL) cholesterol in type 2 diabetes mellitus. Data on changes in LDL cholesterol, adverse cardiac events (ACEs), glycated hemoglobin (HbA1c), and fasting blood glucose (FBG) were pooled in a meta-analysis. Data from dose comparison trials were separately pooled, and meta-analysis was conducted by using RevMan (5.4.1) and R (4.1.2). Dapagliflozin increased LDL cholesterol by 2.33 mg/dL (95% CI, 1.46 to 3.19; I2 = 0%; P <.00001), increased risk of ACEs by 1.56 (95% CI, 1.02 to 2.39; I2 = 0%; P <.04), decreased HbA1c by −0.41% (95% CI, −0.44 to −0.39; I2 = 85%; P <.00001), and decreased FBG by −13.51 mg/dL (95% CI, −14.43 to −12.59; I2 = 92%; P <.00001) versus any placebo or active comparator. Dapagliflozin 10 mg monotherapy increased LDL cholesterol by 1.71 mg/dL (95% CI, −1.20 to 4.62; I2 = 53%; P =.25) versus a 5 mg dose and by 1.04 mg/dL (95% CI, −1.17 to 3.26; I2 = 62%; P =.36) versus a 2.5 mg dose. Dapagliflozin 10 mg monotherapy increased LDL cholesterol by 3.13 mg/dL (95% CI, 1.31 to 4.95; I2 = 0%; P =.0008), increased the risk of ACEs by 1.26 (95% CI, 0.56 to 2.87; I2 = 0%; P =.58), decreased HbA1c by −0.4% (95% CI, −0.45 to −0.35; I2 = 89%; P <.00001), and decreased FBG by −8.39 mg/dL (95% CI, −10 to −6.77; I2 = 96%; P <.00001) versus a placebo or active comparator. Dapagliflozin monotherapy resulted in a minimal but statistically significantly (P =.0002) increase in LDL cholesterol. However, this minor change does not increase the risk of ACEs (P =.17) when compared with placebo or active comparator. © 2024, The American College of Clinical Pharmacology.
Authors : Martha S.; Jangam P.H.; Bhansali S.G.
Source : John Wiley and Sons Inc
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.1002/jcph.6105 |
| ISSN | 00912700 |
| Volume | 64 |
You can download the article here
If You have any problem, contact us here