Here are the Physical exercise improved the hematological effect of vitamin D in type 2 diabetes mellitus-induced nephrotoxicity in rats journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.
Physical benefit of exercise, physical exercise profits little, how exercise improves health, can exercise increase hemoglobin, article on benefits of physical exercise, hemodynamic response to exercise, can exercise lower hemoglobin, the benefits of physical exercise.
Physical exercise improved the hematological effect of vitamin D in type 2 diabetes mellitus-induced nephrotoxicity in rats
Introduction: Globally, one of the major causes of renal dysfunction is diabetes mellitus (DM), and diabetic-induced nephrotoxicity has been linked with anemia. Presently, numerous antidiabetic drugs have been designed for the management of this disorder but they possess their undesirable effects such as anemia and acute kidney injury. Hence, we explore the use of vitamin D with or without exercise for the management of DM-induced renal dysfunction.
Methods: Thirty-six (36) Wistar rats were randomly separated into six (6) groups: control (vehicle treated), diabetes untreated (HFD + STZ), diabetes + vitamin D (HFD + STZ + vitamin D), diabetes + exercise (HFD + STZ + exercise), diabetes + vitamin D + exercise (HFD + STZ + vitamin D+ exercise), diabetes + metformin (HFD + STZ + metformin).
Results: Vitamin D with or without exercise significantly reduced T2DM-induced hyperglycemia. Also, a decrease in T2DM-induced increase in urea, creatinine, lactate dehydrogenase, lactate, cholesterol, and triglyceride and a rise in DM-associated reduction in high-density lipoprotein. These events were associated with a significant increase in red blood cells, hematocrit value, hemoglobin, erythropoietin, and a decrease in white blood cell count. Furthermore, vitamin D with or without exercise reversed T2DM-induced increase in pro-oxidant and pro-inflammatory markers. This observed oxido-inflammatory response was associated with a significant increase in xanthine oxidase activities and uric acid concentration. Interestingly, better recovery rates from DM-associated hematological imbalance were discovered in rats co-treated with vitamin D and exercise.
Conclusion: Our findings revealed that exercise enhanced the hematological effect of vitamin D in HFD + STZ-induced T2DM animals. © 2024 The Authors
Authors : Abdulrahim H.A.; Odetayo A.F.; David A.T.; Abdulquadri Y.F.; Sheu R.O.; Oluwafemi P.K.; Okesina K.B.; Olayaki L.A.
Source : Elsevier B.V.
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.1016/j.bbrep.2024.101839 |
| ISSN | 24055808 |
| Volume | 40 |
You can download the article here
If You have any problem, contact us here