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The acetylation of Ganoderma applanatum polysaccharides on ameliorating T2DM-induced hepatic and colonic injuries by modulating the Nrf2/keap1-TLR4/NFκB-Bax/Bcl-2 pathways
It was imperative to discover and utilize high-efficiency, non-toxic substances for the prevention and management of type 2 diabetes mellitus (T2DM) and its associated complications, given the escalating prevalence and significant global health burden. In the present study, the acetylated Ganoderma applanatum polysaccharide (A-GAP) was successfully obtained and characterized, demonstrating excellent efficacy in ameliorating organ damage induced by T2DM through targeted modulation of the gut-liver axis. The physiological and molecular biological findings indicated that A-GAP may modulate the Nrf2/Keap1-TLR4/NFκB-Bax/Bcl-2 signaling pathway network, thereby mitigating oxidative stress and the subsequent inflammatory response, ultimately alleviating the inhibitory effects of IRS and insulin resistance. Besides, the regulatory impact of A-GAP on the gut-liver axis had been confirmed by its ability to maintain intestinal barrier integrity and increase levels of intestinal tight j unction proteins, effectively preventing endotoxin translocation to the liver. This discovery highlighted the potential of A-GAP as a promising option for functional or nutritional foods and pharmaceuticals in managing T2DM and its complications, showcasing the significance of acetylation in enhancing the bioactivities of natural substances. © 2025
Authors : Zhang Y.; Li X.; Xu S.; Li J.; Shi L.; Wang Z.; Chen P.; Jia L.; Zhang J.
Source : Elsevier B.V.
Article Information
| Year | 2025 |
| Type | Article |
| DOI | 10.1016/j.ijbiomac.2025.140055 |
| ISSN | 01418130 |
| Volume |
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