MOTS-c modulates skeletal muscle function by directly binding and activating CK2

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MOTS-c modulates skeletal muscle function by directly binding and activating CK2

MOTS-c is a mitochondrial microprotein that improves metabolism. Here, we demonstrate CK2 is a direct and functional target of MOTS-c. MOTS-c directly binds to CK2 and activates it in cell-free systems. MOTS-c administration to mice prevented skeletal muscle atrophy and enhanced muscle glucose uptake, which were blunted by suppressing CK2 activity. Interestingly, the effects of MOTS-c are tissue-specific. Systemically administered MOTS-c binds to CK2 in fat and muscle, yet stimulates CK2 activity in muscle while suppressing it in fat by differentially modifying CK2-interacting proteins. Notably, a naturally occurring MOTS-c variant, K14Q MOTS-c, has reduced binding to CK2 and does not activate it or elicit its effects. Male K14Q MOTS-c carriers exhibited a higher risk of sarcopenia and type 2 diabetes (T2D) in an age- and physical-activity-dependent manner, whereas females had an age-specific reduced risk of T2D. Altogether, these findings provide evidence that CK2 is require d for MOTS-c effects. © 2024 The Author(s)

Authors : Kumagai H.; Kim S.-J.; Miller B.; Zempo H.; Tanisawa K.; Natsume T.; Lee S.H.; Wan J.; Leelaprachakul N.; Kumagai M.E.; Ramirez R., II; Mehta H.H.; Cao K.; Oh T.J.; Wohlschlegel J.A.; Sha J.; Nishida Y.; Fuku N.; Dobashi S.; Miyamoto-Mikami E.; Takaragawa M.; Fuku M.; Yoshihara T.; Naito H.; Kawakami R.; Torii S.; Midorikawa T.; Oka K.; Hara M.; Iwasaka C.; Yamada Y.; Higaki Y.; Tanaka K.; Yen K.; Cohen P.

Source : Elsevier Inc.