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Complete central airway obstruction from aggressive mucormycosis in a patient with acute myeloid leukaemia
A woman in her 30s with type 2 diabetes and morbid obesity presented with flu-like symptoms, persistent cough and mild dyspnoea, unresponsive to pneumonia treatment. Diagnosed with acute myeloid leukaemia, she was started on induction chemotherapy. Despite prophylactic antifungal and antibacterial therapy, she developed a fever, a right upper lobe opacity and a complete airway obstruction by a large endobronchial mass in the right main stem. Bronchoscopy with biopsy and PCR confirmed mucormycosis. Although a combined antifungal regimen was started promptly, her condition worsened, leading to acute respiratory distress syndrome, tracheo-pleural fistulas and extensive necrotic mucosa in the airways. Surgical intervention was not feasible, and she was transitioned to hospice. Complete central airway obstruction and trachea-pleural fistula are rare manifestations of pulmonary mucormycosis. We conduct a literature review of endobronchial mucormycosis to highlight the importance of early recognition and a multimodal treatment approach to improve outcomes. © BMJ Publishing Group Limited 2024.
Authors : Nguyen H.D.; Nhi Vo L.Y.; Ho A.T.N.
Source : BMJ Publishing Group
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.1136/bcr-2024-263366 |
| ISSN | 1757790X |
| Volume | 17 |
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