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Circulating T Cell Subsets in Type 1 Diabetes
Type 1 diabetes (T1D) is a complex disease driven by the immune system attacking the insulin-producing beta cells in the pancreas. Understanding the role of different T cell subpopulations in the development and progression of T1D is crucial. By employing flow cytometry to compare the characteristics of T cells, we can pinpoint potential indicators of treatment response or therapeutic inefficacy. Our study reveals elevated prolactin (PRL) levels in T1D patients, along with a decreased production of key cytokines. Additionally, PD1 appears to play a significant role in T1D. Notably, PRL levels correlate with an earlier disease onset and a specific T cell phenotype, hinting at the potential influence of PRL. These findings highlight the need for further research to identify promising cellular targets for more effective and tailored therapies. © 2025 by the authors.
Authors : Ferreira-Hermosillo A.; Santana-Sánchez P.; Vaquero-GarcĂa R.; GarcĂa-Sáenz M.R.; Castro-RĂos A.; Chávez-Rueda A.K.; GĂłmez-DĂaz R.A.; Chávez-Sánchez L.; Legorreta-Haquet M.V.
Source : Multidisciplinary Digital Publishing Institute (MDPI)
Article Information
| Year | 2025 |
| Type | Article |
| DOI | 10.3390/cells14010048 |
| ISSN | 20734409 |
| Volume | 14 |
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