Here are the Heterogeneous enhancer states orchestrate β cell responses to metabolic stress journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.
Heterogeneous enhancer states orchestrate βεβαιωση, heterogeneous enhancer states orchestrated, heterogeneous enhancer states orchestrate βραχυχρονια, heterogeneous enhancer states orchestrate definition, heterogeneous enhancer states orchestrate βοοκινγ, heterogeneous enhancer states orchestrate β cell responses to thank, heterogeneous enhancer states orchestrate β cell responses in catholic mass, heterogeneous enhancer states orchestrate β cell responses synonym.
Heterogeneous enhancer states orchestrate β cell responses to metabolic stress
Obesity-induced β cell dysfunction contributes to the onset of type 2 diabetes. Nevertheless, elucidating epigenetic mechanisms underlying islet dysfunction at single cell level remains challenging. Here we profile single-nuclei RNA along with enhancer marks H3K4me1 or H3K27ac in islets from lean or obese mice. Our study identifies distinct gene signatures and enhancer states correlating with β cell dysfunction trajectory. Intriguingly, while many metabolic stress-induced genes exhibit concordant changes in both H3K4me1 and H3K27ac at their enhancers, expression changes of specific subsets are solely attributable to either H3K4me1 or H3K27ac dynamics. Remarkably, a subset of H3K4me1+H3K27ac- primed enhancers prevalent in lean β cells and occupied by FoxA2 are largely absent after metabolic stress. Lastly, cell-cell communication analysis identified the nerve growth factor (NGF) as protective paracrine signaling for β cells through repressing ER stress. In summary, our fin dings define the heterogeneous enhancer responses to metabolic challenges in individual β cells. © The Author(s) 2024.
Authors : Wang L.; Wu J.; Sramek M.; Obayomi S.M.B.; Gao P.; Li Y.; Matveyenko A.V.; Wei Z.
Source : Nature Research
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.1038/s41467-024-53717-0 |
| ISSN | 20411723 |
| Volume | 15 |
You can download the article here
If You have any problem, contact us here