Here are the Synthesis, characterization and α-amylase inhibition activity of new family of tetrapodal ligands with pyrazole-tetrazole subunits journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.
Synthesis characterization and α amylase inhibition psychology, synthesis characterization and α amylase assay, synthesis characterization and α amylase và protease, synthesis characterization and biomedical application of silver nanoparticles, synthesis characterization and α amylase inhibition zone, synthesis characterization and nitration of tris acetylacetonato cobalt iii, synthesis characterization and ακτοπλοικα, synthesis characterization and α amylase sigma.
Synthesis, characterization and α-amylase inhibition activity of new family of tetrapodal ligands with pyrazole-tetrazole subunits
New family of tetrapodal compounds entitled 3-(bis((5-methyl-1-((2-isopentyl-2H-tetrazol-5-yl)methyl)-1H-pyrazol-3 yl)methyl)amino)propan-1-ol.(T1),2-(4-(bis((5-methyl-1-((2-propyl-2H-tetrazol-5-yl)methyl)-1H-pyrazol-3-yl)methyl)amino)phenyl)ethan-1-ol.(T2),N,N-bis((1-((2-isopentyl-2H-tetrazol-5-yl)methyl)-5-methyl-1H-pyrazol-3-yl)methyl)propan-1-amine.(T3).and.N,N-bis((1-((2-isopentyl-2H-tetrazol-5-yl)methyl)-5-methyl-1H-pyrazol-3-yl)methyl)propan-2 amine (T4) were synthesised as drug candidates to treat Type 2 diabetes. Their structures as the intermediates compounds were ensured by NMR and FTIR analysis as well as the spectrometric methods including high-resolution mass spectrometry and elemental analysis. The tetrapodal molecules were obtained in moderate yields in the range of 37–45 %. Their anti-diabetic activity was evaluated based on their α-amylase inhibition potency by determining their IC50 values. The obtained results showed that the tetrapodal compounds posses s potent α−amylase inhibition activity 3 to 236 times higher than that of the acarbose, used as positive control. These findings were also supported by docking calculations. © 2024 Elsevier B.V.
Authors : Oulous A.; Cherfi M.; Daoudi N.E.; Harit T.; Yahyi A.; Bnouham M.; Malek F.
Source : Elsevier B.V.
Article Information
| Year | 2025 |
| Type | Article |
| DOI | 10.1016/j.molstruc.2024.140254 |
| ISSN | 00222860 |
| Volume | 1321 |
You can download the article here
If You have any problem, contact us here