Exploring Structural and Molecular Features of Sciatic Nerve Lesions in Diabetic Neuropathy: Unveiling Pathogenic Pathways and Targets

Here are the Exploring Structural and Molecular Features of Sciatic Nerve Lesions in Diabetic Neuropathy: Unveiling Pathogenic Pathways and Targets journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.

Exploring structural and social determinants, exploring structural and molecular features in tagalog, exploring structural and steel, exploring structural and molecular features socks, exploring structural and molecular features of down syndrome.

Exploring Structural and Molecular Features of Sciatic Nerve Lesions in Diabetic Neuropathy: Unveiling Pathogenic Pathways and Targets

Lesioned fascicles (LFs) in the sciatic nerves of individuals with diabetic neuropathy (DN) correlate with clinical symptom severity. This study aimed to characterize the structural and molecular composition of these lesions to better understand DN pathogenesis. Sciatic nerves from amputees with and without type 2 diabetes (T2D) were examined using ex vivo magnetic resonance neurography, in vitro imaging, and proteomic analysis. Lesions were only found in T2D donors and exhibited significant structural abnormalities, including axonal degeneration, demyelination, and impaired blood-nerve barrier (BNB). Although non-LFs from T2D donors showed activation of neuroprotective pathways, LFs lacked this response and instead displayed increased complement activation via the classical pathway. The detection of liver-derived acute-phase proteins suggests that BNB disruption facilitates harmful interorgan communication between the liver and nerves. These findings reveal key molecular me chanisms contributing to DN and highlight potential targets for therapeutic intervention. © 2024 by the American Diabetes Association.

Authors : Schwarz D.; Le Marois M.; Sturm V.; Peters A.S.; Longuespée R.; Helm D.; Schneider M.; Eichmüller B.; Hidmark A.S.; Fischer M.; Kender Z.; Schwab C.; Hausser I.; Weis J.; Dihlmann S.; Böckler D.; Bendszus M.; Heiland S.; Herzig S.; Nawroth P.P.; Szendroedi J.; Fleming T.

Source :