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Investigating the Relationship Between Lipid-Lowering Agents and the Complications of Diabetic Retinopathy
BACKGROUND AND OBJECTIVE: As the therapeutic efficacy of lipid-lowering agents (LLA) against diabetic retinopathy (DR) remains controversial, this study aimed to evaluate whether various LLA therapies are associated with a reduced risk of DR progression. PATIENTS AND
METHODS: This retrospective study of the medical records of adults with type 2 diabetes mellitus and DR compared the risk of adverse progression of DR between patients who received statins, fibrates, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, and no LLA (control).
RESULTS: Patients in the statin cohort had a reduced rate of progression to proliferative DR compared to controls (HR = 0.30, CI = 0.11 to 0.83). The PCSK9 inhibitor cohort had a reduced risk of progressing to other secondary complications of DR compared to the control (RR = 0.52, CI = 0.43 to 0.64), statin (RR = 0.69, CI = 0.61 to 0.79), and fibrate (RR = 0.67, CI = 0.59 to 0.77) co horts. CONCLUSIONS: These findings suggest use of statins and PCSK9 inhibitors are associated with a reduced risk of adverse progression of DR. © 2024 Slack Incorporated. All rights reserved.
Authors : Jeong H.; Shaia J.K.; Talcott K.E.; Singh R.P.
Source : Slack Incorporated
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.3928/23258160-20240729-03 |
| ISSN | 23258160 |
| Volume | 55 |
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