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Fat and insulin resistance, adipose tissue function, insulin resistance in obesity, insulin resistance and impaired adipogenesis, insulin effect on adipose tissue, insulin resistance in children, adipose tissue and insulin resistance, insulin resistance in kids.
Adipose tissue insulin resistance in children and adolescents: linking glucose and free fatty acid metabolism to hepatic injury markers
Obesity is one of the leading causes of the development of insulin resistance, diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD) in children. With the progression of insulin resistance, both glucose and free fatty acid (FFA) plasma levels are elevated, leading to cardiometabolic complications such as impaired glucose tolerance (IGT), type 2 diabetes, and liver fat accumulation. In this study, oral minimal models were used to estimate insulin sensitivity indexes (SI and SIFFA) in 375 adolescents with obesity. Differences between normal glucose tolerance (NGT) and IGT were assessed by using Mann–Whitney U test, while the relationship between insulin sensitivities and plasma alanine transaminase (ALT) was assessed using Spearman correlation and linear regression model of the log-transformed variables. Also, 48 youths repeated the oral glucose tolerance test and the measurement of liver function test after 〜1.3 yr of follow-up. SI was statisticall y different between NGT and IGT (P < 10−6) and correlated with each other (r = 0.7, P < 10−6). Lipolysis was completely suppressed after 30 min in NGT, compared with 120 min in IGT. SI and SIFFA were both statistically correlated with ALT (r = −0.19, P < 10−3). Also, the percentages of variation of SIFFA and ALT between the first and second visits correlated significantly (r = −0.47, P = 0.002). FFA minimal model can be used to estimate adipose tissue lipolysis in youths with obesity. The relationship of SI and SIFFA with ALT, along with the progression of the impairment of adipose tissue insulin sensitivity, shows that systemic insulin resistance underlies the relationship of glucose and FFA metabolism with hepatic damage. Copyright © 2024 the American Physiological Society.
Authors : Bonet J.; Weiss R.; Galderisi A.; Dalla Man C.; Caprio S.; Santoro N.
Source : American Physiological Society
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.1152/ajpendo.00270.2024 |
| ISSN | 01931849 |
| Volume | 327 |
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