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Terminalia catappa aqueous extract reduces hyperglycaemia and oxidative stress in diabetic-hypercholesterolemic rats
Background: Terminalia catappa is an important medicinal plant. Plants from the genus Terminalia have been reported for antidiabetic effects. Objective: To study effect of Terminalia catappa leaves aqueous extract in type 2 diabetic rats. Materials and
methods: High-fat diet (HFD) and a low dose of streptozotocin (35 mg/kg, i.p.) were used for inducing type 2 diabetes in rats; streptozotocin was injected after two weeks of dietary modification with HFD. HFD was continued throughout the study. Doses of 500 and 1000 mg/kg of aqueous extract of Terminalia catappa were used as a treatment for six weeks. At the end of the study, biochemical and oxidative stress parameters were estimated. Histopathology and immunohistochemistry of pancreatic tissue were performed.
Results: Significant decrease (p < 0.01, p < 0.001) was observed in glucose levels of diabetic animals treated with T. catappa extract at both dose l evels when compared with diabetic control group. Treatment with aqueous extract reduced cholesterol levels significantly (p < 0.05). After receiving 1000 mg/kg of extract, the triglyceride level was significantly lowered (p < 0.01) in the diabetic rats. Extract treatment enhanced the insulin sensitivity index (ISI), while insulin levels and HOMA-IR were markedly reduced. Treatment with 1000 mg/kg of extract significantly enhanced the levels of GSH and catalase. Histopathological analysis of the pancreas showed that damage caused by hyperglycemia was prevented in the extract-treated groups. Pancreatic tissue showed an increased expression of SIRT1 in extract-treated animals.
Conclusion: The current study's findings prove that the extract has remarkable antidiabetic effects. © 2024 The Authors
Authors : Agrawal O.D.; Kulkarni Y.A.
Source : Elsevier B.V.
Article Information
| Year | 2025 |
| Type | Article |
| DOI | 10.1016/j.jaim.2024.101025 |
| ISSN | 09759476 |
| Volume | 16 |
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