Here are the Neuropathy and the metabolic syndrome journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.
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Neuropathy and the metabolic syndrome
Obesity and the metabolic syndrome (MetS) are major global health challenges that contribute significantly to the rising prevalence of type 2 diabetes (T2D) and neuropathy. Neuropathy, a common and disabling complication of T2D, is characterized by progressive distal-to-proximal axonal degeneration, driven in part by mitochondrial dysfunction in both neurons and axons. Recent evidence points to the toxic effects of saturated fatty acids on peripheral nerve health, with studies demonstrating that these fats impair mitochondrial function and bioenergetics, leading to distal axonal loss. Conversely, monounsaturated fatty acids are found to be neuroprotective, restoring mitochondrial function and preventing neuropathy. These findings suggest that dietary factors play a crucial role in the pathogenesis of neuropathy associated with metabolic dysregulation and emphasize the need for lifestyle interventions and therapies that target these newly identified mechanisms. © 2024 The Aut hor(s)
Authors : Piccolo N.; Wiggers A.; Koubek E.J.; Feldman E.L.
Source : Elsevier B.V.
Article Information
| Year | 2025 |
| Type | Article |
| DOI | 10.1016/j.ensci.2024.100542 |
| ISSN | 24056502 |
| Volume | 38 |
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