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Alpha-glucosidase inhibitory and glucoregulatory potential of soy protein fermented with a bacterium (Bacillus subtilis PM_NEIST_3) isolated from Hawaijar
Soybean-derived proteins are known to exert hypoglycemic effects; however, some soy proteins may cause anti-nutritional effects. Fermentation of soybean promotes hydrolysis of major anti-nutrient proteins and generation of bioactive peptides with antidiabetic potency. The present study aims to screen antidiabetic potential of protein isolates from ethnic fermented soybean (FS) of North-East (NE) India and to develop fermented soy protein isolate (FSPI) under controlled conditions by using the proficient bacteria isolated from the most effective FS with sound antidiabetic activity. Results showed that Hawaijar, a FS of Manipur, NE India, exhibited significant α-glucosidase and α-amylase inhibitory potential among the well-known FS of NE India under investigation. Thereafter, in the laboratory, the fermented soy protein isolate (FSPI-BS) was prepared by fermenting the SPI using a bacterial strain (Bacillus subtilis PM_NEIST_3) isolated from Hawaijar. The FSPI-BS generated by 72h fermentation exhibited significant α-glucosidase inhibitory potential. Further in vitro studies revealed that FSPI-BS promoted muscle glucose uptake and metabolism against high-glucose exposure via stimulating the PI3K/AKT/GLUT4 signaling cascade. In vivo studies using sucrose-induced Wistar rats demonstrated the inhibitory effect of FSPI-BS on postprandial blood glucose elevation. Moreover, studies with high-fat diet-fed model of type 2 diabetes revealed the benefits of FSPI-BS supplementation in improving glycemic parameters, glucose tolerance, insulin sensitivity, and skeletal muscle glucose metabolism. SDS-PAGE and western-blotting data unraveled a modification in protein profile with reduction in allergens and other baneful proteins in FSPI-BS. Therefore, FSPI-BS can be effectively used in managing hyperglycemia with no side effects. © 2024 Elsevier Ltd
Authors : Das D.; Kabir M.E.; Borah A.; Phukan T.; Kaita J.; Manna P.
Source : Elsevier Ltd
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.1016/j.fbio.2024.105465 |
| ISSN | 22124292 |
| Volume | 62 |
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