Here are the Retinal and Choroidal Phenotypes Across Novel Subtypes of Type 2 Diabetes Mellitus journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.
Retinal and retinol, choroidal vs retinal detachment radiology, choroidal retinal atrophy, retinal and ophthalmic consultants, choroidal detachment vs retinal detachment, retinal and retinol difference.
Retinal and Choroidal Phenotypes Across Novel Subtypes of Type 2 Diabetes Mellitus
Purpose: To investigate longitudinal changes in choroidal thickness (CT) and ganglion cell-inner plexiform layer thickness (GC-IPLT) across distinct phenotypes of type 2 diabetes mellitus (T2DM) patients. Design: Prospective cohort study.
Methods: T2DM patients were categorized into 5 groups (SAID, SIDD, SIRD, MOD, and MARD) using K-means clustering based on β-cell function and insulin resistance. Swept-source optical coherence tomography measured baseline and 4-year follow-up CT and GC-IPLT. Linear mixed-effects models assessed absolute and relative changes in CT and GC-IPLT across subtypes.
Results: Over a median 4.11-year follow-up, CT and GC-IPLT decreased significantly across all groups. Choroidal thinning rates were most pronounced in SIDD (−6.5 ± 0.53 µm/year and −3.5 ± 0.24%/year) and SAID (−6.27 ± 0.8 µm/year and −3.19 ± 0.37%/year), while MARD showed the slowest thinning rates (−3.63 ± 0.34 µm/year a nd −1.98 ± 0.25%/year). SIRD exhibited the greatest GC-IPLT loss (−0.66 ± 0.05 µm/year and −0.91 ± 0.07%/year), with the least in SIDD (−0.36 ± 0.05 µm/year and −0.49 ± 0.07%/year), all statistically significant (all P < 0.001). Adjusted for confounding variables, SIDD and SAID groups showed faster CT thinning than MARD [−2.57 µm/year (95% CI: −4.16 to −0.97; P = 0.002) and −2.89 µm/year (95% CI: −4.12 to −1.66; P < 0.001), respectively]. GC-IPLT thinning was notably accelerated in SIRD versus MARD, but slowed in SIDD relative to MARD [differences of −0.16 µm/year (95% CI: −0.3 to −0.03; P = 0.015) and 0.15 µm/year (95% CI: 0.03 to 0.27; P = 0.015), respectively]. Conclusions: Microvascular damage in the choroid is associated with SIDD patients, whereas early signs of retinal neurodegeneration are evident in SIRD patients. All these changes may precede the onset of DR. © 2024 Elsevier Inc.
Authors : Liu K.; Li T.; Zhong P.; Zhu Z.; Guo X.; Liu R.; Xiong R.; Huang W.; Wang W.
Source : Elsevier Inc.
Article Information
| Year | 2025 |
| Type | Article |
| DOI | 10.1016/j.ajo.2024.08.039 |
| ISSN | 00029394 |
| Volume | 269 |
You can download the article here
If You have any problem, contact us here