Here are the Exploring the multiple effects of butein on adipogenic differentiation, inflammatory responses, and glucose metabolism in cellular models journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.
Suggest two possible effects, exploring the solar system, explore the effects o, one cause multiple effects examples, exploring the ancient city of pteria pdf, exploring the world, suggest two possible effects, multiple effects reported as one result, exploring the best dating sites of 2024.
Exploring the multiple effects of butein on adipogenic differentiation, inflammatory responses, and glucose metabolism in cellular models
Obesity is a significant risk factor for the development of type 2 diabetes due to its association with increased oxidative stress and inflammation. This study investigates the potential therapeutic effects of butein, a plant-derived polyphenol used as a dietary supplement, on adipogenic differentiation in 3T3-L1 cells, as well as its effects on inflammation and glucose metabolism in co-cultured 3T3-L1 and RAW264 cells treated with lipopolysaccharide (LPS). While butein did not significantly affect lipid accumulation in adipocytes, it significantly upregulated the mRNA expression of genes involved in adipogenic differentiation. In addition, butein demonstrated the ability to reduce reactive oxygen species levels in adipocytes. In co-culture with LPS-stimulated cells, butein exhibited anti-inflammatory properties by suppressing the expression of pro-inflammatory cytokines. Although its efficacy in reversing LPS-induced glucose metabolism in 3T3-L1 adipocytes was limited, butei n significantly inhibited GLUT1 expression in LPS-stimulated RAW264 cells. The effects of butein on adipogenic differentiation, inflammation and glucose metabolism were found to be concentration dependent, suggesting potential protective benefits in co-cultured cell models under LPS stimulation. © 2024 The Authors
Authors : Ohmoto M.; Matsuya A.; Mouri M.; Takemoto M.; Daikoku T.
Source : Elsevier Ltd
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.1016/j.focha.2024.100851 |
| ISSN | 2772753X |
| Volume | 5 |
You can download the article here
If You have any problem, contact us here