Here are the Clinical and genetic associations for night eating syndrome in a patient biobank journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.
Clinical and genetic associations for executive assistants, clinical and genetic associations for night eating hypnosis, clinical and genetic associations for night eating treatment, clinical and genetic study of japanese patients with type 3 gaucher disease, clinical and genetic associations for event, clinical and radiologic correlation, clinical and genetic associations for night eating and drinking, clinical and genetic associations for night eating syndrome, clinical and genetic associations for meeting.
Clinical and genetic associations for night eating syndrome in a patient biobank
Objective: Night eating syndrome (NES) is an eating disorder characterized by evening hyperphagia. Despite having a prevalence comparable to some other eating disorders, NES remains sparsely investigated and poorly characterized. The present study examined the phenotypic and genetic associations for NES in the clinical Mass General Brigham Biobank. Method: Cases of NES were identified through relevant billing codes for eating disorders (F50.89/F50.9) and subsequent chart review; patients likely without NES were set as controls. Other diagnoses were determined from billing codes and collapsed into one of 1,857 distinct phenotypes based on clinical similarity. NES associations with diagnoses were systematically conducted in phenome-wide association scans using logistic regression models with adjustments for age, sex, race, and ethnicity. Polygenic scores for six related traits, namely for anorexia nervosa, depression, insomnia, sleep apnea, obesity, and type 2 diabetes were tes ted for associations with NES among participants of European ancestry using adjusted logistic regression models.
Results: Phenome-wide scans comparing patients with NES against controls (cases n = 88; controls n = 64,539) identified associations with 159 clinical diagnoses spanning 13 broad disease groups including endocrine/metabolic and digestive diseases. Notable associations were evident for bariatric surgery, vitamin D deficiency, sleep disorders (sleep apnea, insomnia, and restless legs syndrome), and attention deficit hyperactivity disorder. The polygenic scores for insomnia and obesity were associated with higher odds of NES (insomnia: odds ratio [OR], 1.24; 95% CI, 1.07, 1.43; obesity: 1.98; 95% CI, 1.71, 2.28). Discussion: Complementary phenome-wide and genetic exploratory analyses provided information on unique and shared features of NES, offering insights that may facilitate its precise definition, diagnosis, and the development of targeted therap eutic interventions. © The Author(s) 2024.
Authors : Wilcox H.; Saxena R.; Winkelman J.W.; Dashti H.S.
Source : BioMed Central Ltd
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.1186/s40337-024-01180-z |
| ISSN | 20502974 |
| Volume | 12 |
You can download the article here
If You have any problem, contact us here