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Effects of 5% Coca-Cola Consumption on Metabolic, Renal, and Hepatic Markers in Adult Balb/c Mice
The impact of consuming Coca-Cola increases the energy and the weight at the same time, however, the 5% refers to consuming one can of Coca-Cola daily in the long term. The consumption of 5% Coca-Cola increases food intake, body weight, and contributes to various other disorders in young mice. This work aims to find the effect of Coca-Cola consumption on leptin and insulin resistance, lipid profile, and changes in renal and liver functions in adult mice. In this study, 30 adult male Balb/c mice (8-10 weeks old, weighing 25-30g) were used and divided into three groups. Ten mice received tap water and serve as control group, the other 20 mice received 5% Coca-Cola daily instead of water for different durations and served as restricted groups, ten for 10-day (restricted 1) and the other ten for 30-day (restricted 2). Body weight of all mice was measured at the start and end of the experiment, while the food intake was recorded daily. The mice were killed at different time-points . Blood was collected and used to determine the levels of FBG, HbA1c, leptin and insulin hormones, lipid profile, and liver and kidney function parameters. The insulin resistance was also calculated. The results indicate significant increases in food intake, body weight, leptin, insulin, FBG, HbA1c, and insulin resistance in groups exposed to Coca-Cola. Lipid profiles and liver and kidney function markers also deteriorated, particularly in the group with longer exposure. Prolonged consumption led to increased body weight and leptin levels (indicating leptin resistance), insulin resistance with elevated FBG and HbA1C (suggestive of type 2 diabetes), altered lipid profiles (raising cardiovascular risk), elevated kidney (BU and SCr) and liver function markers (GOT, GPT, ALK), with these effects intensifying over 30 days compared to 10 days. ©2024 The authors.
Authors : Alshammary A.G.; Ali L.Q.; El-Haboby B.T.; Al-Fatah Essa A.A.; Alshammary R.A.A.; Jouda J.
Source : International Information and Engineering Technology Association
Article Information
| Year | 2024 |
| Type | Article |
| DOI | 10.18280/ijdne.190625 |
| ISSN | 17557437 |
| Volume | 19 |
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