Here are the Type 2 diabetes and the minor allele of PNPLA3 consistently identify high-risk metabolic dysfunction associated steatotic liver disease journals presenting the latest research across various disciplines. From social sciences to technology, each article is expected to provide valuable insights to our readers.
Type 2 diabetes in mice, type 2 dm, type 2 diabetes and foot pain, type 2 diabetes food list, type 2 diabetes and diet, type 2 diabetes and gallbladder removal, type 2 diabetes and the military.
Type 2 diabetes and the minor allele of PNPLA3 consistently identify high-risk metabolic dysfunction associated steatotic liver disease
Background: Association of genetic factors with non-invasive tests (NITs) for MASLD has not been well established.
Methods: Clinical and laboratory data, liver biopsy and/or liver stiffness measurement (LSM) by transient elastography were collected from MASLD patients seen in tertiary care hepatology practices. Minor allele frequency for genomic loci rs641738 (MBOAT7), rs58542926 (TM6SF2), rs738409 (PNPLA3), rs62305723 (HSD1713B) were evaluated for association with high ELF (≥11.3), high FIB-4 (≥3.25), high LSM (≥10 kPa), histologic fibrosis (stage 3/4 vs. stages 0–2).
Results: Among 2289 MASLD patients with available polymorphism and liver fibrosis/NIT data [52 ± 13 years, 46 % male, BMI 36.6 ± 9.9, 35 % type 2 diabetes (T2D)], 53 % had high-risk allele (C > G) at rs738409 (PNPLA3), 70 % high-risk allele (C > T) at rs641738 (MBOAT7), 18 % high-risk minor allele (C > T) at rs58542926 (TM6SF2), 1 1 % low-risk minor allele (G > A) at rs62305723 (HSD17b13). Only PNPLA3-rs738409 (47 % CC, 40 % CG, 13 % GG) was significantly associated with higher NIT scores and histologic fibrosis: high ELF 2.8 % CC vs. 8.1 % CG/GG; high FIB-4 4.7 % CC vs. 11.6 % CG/GG; high LSM 10 % vs. 19 %; advanced histologic fibrosis 34 % CC vs. 60 % CG/GG (all p < 0.01). Similar associations of PNPLA3-rs738409 with NITs were observed in a subgroup of MASLD patients with T2D (n = 799; all p < 0.05). The PNPLA3-rs738409 CG/GG genotype, older age and T2D were independently associated with high ELF [OR (95 % CI) = 3.25 (2.03–5.20)], FIB-4 [OR = 2.75 (1.90–3.98)], LSM [OR = 2.71 (1.60–4.59)] scores and advanced histologic fibrosis [OR = 2.56 (1.81–3.62)]. Conclusions: The polymorphism rs738409 in the PNPLA3 gene, T2D, and older age were independent predictors of high-risk MASLD. © 2024
Authors : Younossi Z.M.; Estep J.M.; Felix S.; Lam B.; Younossi Z.; Racila A.; Stepanova M.
Source : Elsevier Ireland Ltd
Article Information
| Year | 2025 |
| Type | Article |
| DOI | 10.1016/j.diabres.2024.111960 |
| ISSN | 01688227 |
| Volume | 219 |
You can download the article here
If You have any problem, contact us here